CASE REPORT
Surgical treatment of central giant cell granuloma of the jaws in children
 
More details
Hide details
1
Department of Maxillofacial Surgery, Regional Children’s Specialized Hospital in Olsztyn, Poland
 
2
Department of Ophthalmology, Regional Children’s Specialized Hospital in Olsztyn, Poland
 
3
Department of Oncological and Reconstructive Surgery, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology Gliwice Branch, Gliwice, Poland
 
 
Submission date: 2017-02-28
 
 
Acceptance date: 2017-05-07
 
 
Online publication date: 2018-03-01
 
 
Publication date: 2019-11-17
 
 
Corresponding author
Maciej Borowiec   

Department of Maxillofacial Surgery, Regional Children’s Specialized Hospital in Olsztyn, Żołnierska 18A, 10-561 Olsztyn, Poland. Tel.: +48 508 333 839.
 
 
Pol. Ann. Med. 2018;25(1):125-129
 
KEYWORDS
ABSTRACT
Introduction:
There has been much debate in the literature regarding the preferred method of central giant cell granulom (CGCG) treatment. Non-surgical methods are widely accepted, including intralesional corticosteroid injections, calcitonin therapy and the rarely used interferon therapy but surgical excision is the preferred method of treatment.

Aim:
The objective of this study was to describe our experience in the surgical treatment of CGCG in the paediatric population.

Case study:
A case study of 9 paediatric patients with the average age of 10 years is discussed in this article. Most patients were diagnosed with mandibular CGCG lesions, and multifocal tumours localized in the mandible and the maxilla were noted in 2 cases.

Results and discussion:
The surgical procedures performed in our department included enucleation (2 patients), en bloc resection (2 patients) and segmental resection (5 patients). Segmental resections require further reconstruction. A surgically created defect is repaired with the involvement of frozen or autologous bone grafts, distraction osteogenesis and microvascular customized multiple tissue flaps.

Conclusions:
Our experience indicates that despite the use of a meticulous surgical technique, patients at risk of tumour recurrence have to remain under strict clinical observation.

 
REFERENCES (10)
1.
Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol. 1953;6(1):159–175. https://doi.org/10.1016/0030-4....
 
2.
Barnes L, Eveson JW, Reichart P, Sidransky D. Pathology and Genetics of Head and Neck Tumours. WHO Classif Tumour. 2005;(9):163–175.
 
3.
Whitaker SB, Waldron CA. Central giant cell lesions of the jaws. A clinical, radiologic, and histopathologic study. Oral Surg Oral Med Oral Pathol. 1993;75(2):199–208. https://doi.org/10.1016/0030-4....
 
4.
de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(5):603–615. https://doi.org/10.1016/j.trip....
 
5.
Chuong R, Kaban LB, Kozakewich H, Perez-atayde A. Central giant cell lesions of the jaws : a clinicopa thologic study. J Oral Maxillofac Surg. 1986;44(9):708–713. https://doi.org/10.1016/0278-2....
 
6.
Farrier SL, Farrier JN, Smart MK, Nash ES. A 10-year review of the occurrence and treatment of central giant cell granulomas, in a District General Hospital. J Oral Pathol Med. 2006;35(6):332–337. https://doi.org/10.1111/j.1600....
 
7.
Faverani LP, Ferreira S, Ferreira GR, Coléte JZ, Aranega AM, Garcia Júnior IR. Central giant cell granuloma in pediatric maxilla: surgical management. J Craniofac Surg. 2014;25(4):e344-6. https://doi.org/10.1097/SCS.00....
 
8.
Bataineh AB, Al-Khateeb T, Rawashdeh MA. The surgical treatment of central giant cell granuloma of the mandible. J Oral Maxillofac Surg. 2002;60(7):756–761. https://doi.org/10.1053/joms.2....
 
9.
Dolanmaz D, Esen A, Mihmanlı A, Işık K. Management of central giant cell granuloma of the jaws with intralesional steroid injection and review of the literature. Oral Maxillofac Surg. 2016;20(2):203–209. https://doi.org/10.1007/s10006....
 
10.
De Lange J, van den Akker HP, Klip H. Incidence and disease-free survival after surgical therapy of central giant cell granulomas of the jaw in The Netherlands: 1990–1995. Head Neck. 2004;26(9):792–795. https://doi.org/10.1002/hed.20....
 
Journals System - logo
Scroll to top