Associations between serum levels of thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3) and clinical symptoms in patients diagnosed with Hashimoto’s thyroiditis
Karol Wiśniewski 1  
,   Monika Bełej 2  
,   Joanna Wojtkiewicz 1  
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Department of Pathophysiology, School of Medicine, Collegium Medicum, University of Wamia and Mazury in Olsztyn, Poland
Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Science and Technology, Poland
Joanna Wojtkiewicz   

Department of Pathophysiology, School of Medicine, Collegium Medicum, University of Wamia and Mazury in Olsztyn, Warszawska 30, 10-082 Olsztyn, Poland.
Submission date: 2019-11-14
Final revision date: 2020-05-18
Acceptance date: 2020-05-18
Online publication date: 2020-10-15
Pol. Ann. Med. 2020;27(2):96–102
Hashimoto’s thyroiditis (HT), with prevalence of about 0.8%, is one of the most common autoimmune disorders in the world. Due to the fact that HT affects level of thyroid hormones, symptoms of HT are from almost every body system.

The aim of this study was to estimate the correlations between symptoms reported by patients with HT and the level of TSH, fT3 and fT4 and also to check the frequency of reporting each symptom at presentation and to estimate the frequency of other co-existing with HT autoimmune diseases.

Material and methods:
This study included 65 patients with HT who decided to complete the online survey.

Results and discussion:
The most common among the reported symptoms were fatigue (77%), sleepiness (60%) and weak concentration (57%). The results also showed higher prevalence of: rheumatoid arthritis, coeliac disease, systemic lupus erythematous, diabetes mellitus type 1, inflammatory bowel disease and atopic dermatitis than in general population. Significant correlations were found between TSH level and the symptoms including: weak concentration (P = 0.0002), easy freezing (P = 0.02) and body weight gain (P = 0.02). There was also a correlation between level of fT3 and physical exercise (P = 0.02).

The findings in this study suggest that there is a higher relative risk for some autoimmune disorders (especially rheumatoid arthritis, coeliac disease and systemic lupus erythematous) for people with HT. The findings also suggest that some symptoms of HT correlate with the level of thyroid parameters.

None declared.
None declared.
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