RESEARCH PAPER
Characteristics of mucinous breast cancer: Epidemiology, prognostic features, and pathological characteristics
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1
Students’ Scientific Organization of Cancer Cell Biology, Department of Oncology Propaedeutics, Medical University of Warsaw, Poland
2
Department of Oncology Propaedeutics, Medical University of Warsaw, Poland
3
Department of Pathomorphology, Military Institute of Medicine – National Research Institute, Poland
4
Maria Sklodowska-Curie Medical Academy in Warsaw, Poland
Submission date: 2025-06-15
Final revision date: 2025-10-24
Acceptance date: 2025-10-26
Online publication date: 2026-05-12
Publication date: 2026-05-12
Corresponding author
Aleksandra Fryncel
Students’ Scientific Organization of Cancer Cell Biology, Department of Oncology Propaedeutics, Medical University of Warsaw, Warsaw, Poland
Pol. Ann. Med. 2026;33:85-90
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Although many studies have already investigated breast carcinoma, they mainly focused on the most common types. Therefore, there is a lack of information about the rarer ones, such as mucinous breast carcinoma (MBC).
Aim:
To summarize the knowledge gained so far about the epidemiology, etiology, prognostic factors, pathomorphological changes, and treatment of MBC and to present its characteristics based on original data.
Material and methods:
A PubMed literature review was conducted. Tissue samples from 1122 patients with suspected or diagnosed breast carcinoma were analyzed. Tumor types were identified using hematoxylin and eosin staining, and immunohistochemistry was used to assess estrogen (ER), progesterone (PR), and HER2/neu receptor expression.
Results and discussion:
The review identified pure MBC (PMC) and mixed MBC (MMC) as two subtypes of the tumor. Our results showed that PMC was dominant subtype. PMC patients were older at the time of the diagnosis than MMC. None of the females had distant metastases and only two presented with positive lymph node status. ER expression without PR expression was recognized in three cases, HER2 in four, and both ER and PR in fourteen Patients with PMC showed more frequent expression of ER and PR than those with MMC.
Conclusions:
Overall, this study focused on the importance of subtype differentiation and the evaluation of clinical features in determining prognosis and selecting appropriate therapy for MBC. Additionally, we indicated factors that may influence patient prognosis such as hormonal status, lymph node involvement and age.
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