RESEARCH PAPER
Epstein-Barr virus, human cytomegalovirus, human herpesvirus 6 and 7, human adenovirus, John Cunningham virus, and BK virus are not associated with gliomas in humans
 
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1
Department of Clinical Nursing, Medical University of Warsaw, Poland
2
Department of Neurosurgery, John Paul II Western Hospital, Grodzisk Mazowiecki, Poland
3
Department of Immunology, Transplantology, and Internal Diseases, Medical University of Warsaw, Poland
CORRESPONDING AUTHOR
Bożena Czarkowska-Pączek   

Department of Clinical Nursing, Medical University of Warsaw, E. Ciolka 27, 01-445 Warsaw, Poland. Tel./Fax: +4822 836 09 72.
Submission date: 2021-07-06
Final revision date: 2021-11-10
Acceptance date: 2021-11-10
Online publication date: 2021-11-17
 
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The literature points to several viruses associated with brain carcinogenesis, including gliomas.

Aim:
The aim of this study was to assess the presence of several viruses in gliomas and plasma from patients with brain tumor and the possible association of viral positivity with the clinical course.

Material and methods:
The study group consisted of 37 patients with gliomas who were subjected to surgery. Mean patient age was 54.59 (SD 15.85) years. The presence of viral DNA was assessed using real-time polymerase chain reaction.

Results and discussion:
We did not confirm any BK virus, John Cunningham virus, or human adenovirus-positive gliomas. The percentage of patients with gliomas positive for Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus (HHV) 6 and 7 was 18.9%, 8.1%, 2.7%, and 10.8%, respectively. We did not confirm the co-occurrence of glioma and plasma viral positivity. Fisher’s test did not reveal the influence of viral infection on the risk of death. We did not detect any differences regarding sex, WHO classification of gliomas, or the functional impairment evaluated by the Karnofsky scale index at admission to the hospital in the group of patients positive or negative for EBV, CMV, or HHV6.

Conclusions:
We cannot confirm an association of the investigated viruses with gliomas.

FUNDING
No external funding.
CONFLICT OF INTEREST
None.
 
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