Gout, hyperuricemia and chronic kidney disease: New treatment possibilities
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3rd Department of Internal Medicine and Nephrology, Regional Specialist Hospital, Włocławek, Poland
Department of Nephrology, Hypertension and Internal Medicine, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Poland
Submission date: 2016-02-18
Acceptance date: 2016-04-07
Online publication date: 2016-05-04
Publication date: 2020-03-24
Corresponding author
Tomasz Stompór   

Department of Nephrology, Hypertension and Internal Medicine, Medical Faculty, University of Warmia and Mazury in Olsztyn, Żołnierska 18, 10-561 Olsztyn, Poland. Tel.: +48 89 5386219; fax: +48 89 5386550.
Pol. Ann. Med. 2016;23(2):195-201
Gout remains one of the most frequent diseases of joints and soft tissues. Apart from symptomatic gout, uric acid is also involved in pathogenesis and progression of several other diseases such as chronic kidney disease, hypertension, metabolic syndrome and cardiovascular disease.

To describe the role of uric acid in the development of chronic diseases such as chronic kidney disease, hypertension, metabolic syndrome and cardiovascular disease. We also aimed to discuss the role of uric acid in the development of gout, considered the most typical manifestation of hyperuricemia. The important task of our work was also identification of 'classical' and newest therapeutic strategies aimed to lower uric acid level and to improve the diseases that might be triggered with hyperuricemia.

Material and methods:
We searched the latest literature in the field identifying studies describing the different roles of uric acid in the development of several diseases. We also found and described latest clinical trials focused on therapeutic lowering of hyperuricemia.

Results and discussion:
Increasing evidence suggests contribution of uric acid in the development of chronic diseases, including chronic kidney disease, cardiovascular disease, hypertension and metabolic syndrome. The development of these pathologies may be controlled by effective lowering of hyperuricemia using both 'classical' drugs (i.e. allopurinol) and the newer agents (i.e. febuxostat).

Uric acid contributes to the development of several chronic, potentially lifethreatening diseases. Hyperuricemia control should be considered as one of the strategies in their treatment.

None declared.
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