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RESEARCH PAPER
Immune polychemotherapy regimen choice in B-cell non-Hodgkin lymphoma of high and low malignancy based on the identification of the mutational c-myc and BCL 2 genes
1
Department of Management, Kazakh Research Institute of Oncology and Radiology, Almaty, Republic of Kazakhstan
2
Center for Hemoblastosis and Bone Marrow Transplantation, Kazakh Research Institute of Oncology and Radiology, Almaty, Republic of Kazakhstan
3
Center for Hematology and Bone Marrow Transplantation, Kazakh Research Institute of Oncology and Radiology, Almaty, Republic of Kazakhstan
4
Laboratory of Cytogenetic and Moleculear Cytogenetic, Research Institute of Pediatrics and Pediatric Surgery, Almaty, Republic of Kazakhstan
5
Center for Morphological Research, Kazakh Research Institute of Oncology and Radiology, Almaty, Republic of Kazakhstan
Submission date: 2021-01-15
Final revision date: 2021-02-05
Acceptance date: 2021-02-05
Online publication date: 2021-08-20
Corresponding author
Dilyara R. Kaidarova
Kazakh Research Institute of Oncology and Radiology, 480072, 91 Abai Ave., Almaty, Republic of Kazakhstan
Kazakh Research Institute of Oncology and Radiology, 480072, 91 Abai Ave., Almaty, Republic of Kazakhstan
Pol. Ann. Med. 2022;29(1):31-37
KEYWORDS
TOPICS
ABSTRACT
Introduction:
The relevance of research is conditioned by the study of the gene expression profile for the identification of molecular subgroups of non-Hodgkin B-cell lymphomas (NHBCLs) in haematology.
Aim:
The aim of this research was to study the gene expression profile with the identification of molecular subgroups in patients with NHBCLs for personalised treatment.
Material and methods:
This paper is aimed at analysing the frequency and role of expression of c-myc, B-cell lymphoma 2 (BCL 2) proteins and the Ki 67 proliferative index in patients with NHBCLs and conducting personalised therapy to improve the immediate effectiveness and immediate treatment results.
Results and discussion:
The paper presents the results of the use of high-dose polychemotherapy (PCT) in 9 patients out of 80 with NHBCL during co-expression of the c-myc, BCL 2 mutational gene and with high values of the Ki 67 proliferative index. High-dose chemotherapy (HDCT) was performed according to the R+HyperCVAD scheme (6 courses) and hematopoietic stem cell (HSC) autotransplantation improved the immediate effectiveness of therapy, with a complete remission rate of 80% and an event-free survival of 28 months.
Conclusions:
The study of molecular genetic characteristics in 80 patients with NHBCLs revealed co-expression of the c-myc and BCL 2 mutational gene in 9 out of 80 patients, and they differed in the aggressive course, ‘poor’ response to therapy, which predetermined the use of high-dose PCT with transplantation of autologous stem cells.
The relevance of research is conditioned by the study of the gene expression profile for the identification of molecular subgroups of non-Hodgkin B-cell lymphomas (NHBCLs) in haematology.
Aim:
The aim of this research was to study the gene expression profile with the identification of molecular subgroups in patients with NHBCLs for personalised treatment.
Material and methods:
This paper is aimed at analysing the frequency and role of expression of c-myc, B-cell lymphoma 2 (BCL 2) proteins and the Ki 67 proliferative index in patients with NHBCLs and conducting personalised therapy to improve the immediate effectiveness and immediate treatment results.
Results and discussion:
The paper presents the results of the use of high-dose polychemotherapy (PCT) in 9 patients out of 80 with NHBCL during co-expression of the c-myc, BCL 2 mutational gene and with high values of the Ki 67 proliferative index. High-dose chemotherapy (HDCT) was performed according to the R+HyperCVAD scheme (6 courses) and hematopoietic stem cell (HSC) autotransplantation improved the immediate effectiveness of therapy, with a complete remission rate of 80% and an event-free survival of 28 months.
Conclusions:
The study of molecular genetic characteristics in 80 patients with NHBCLs revealed co-expression of the c-myc and BCL 2 mutational gene in 9 out of 80 patients, and they differed in the aggressive course, ‘poor’ response to therapy, which predetermined the use of high-dose PCT with transplantation of autologous stem cells.
FUNDING
None declared.
CONFLICT OF INTEREST
None declared.
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