Influence of odontogenic cysts on immune system – cytometric analysis of T lymphocytes subpopulation
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Chair and Department of Oral Surgery, Medical University in Lublin, Poland
Department of Clinical Genetics, Medical University in Lublin, Poland
Rafał Jamrogiewicz   

Chair and Department of Oral Surgery, Medical University in Lublin, Karmelicka 7, 20-081 Lublin, Poland. Tel.: +4881 528 79 50, Fax: +4881 528 79 51.
Submission date: 2016-09-23
Acceptance date: 2017-06-06
Online publication date: 2018-06-16
Publication date: 2019-11-18
Pol. Ann. Med. 2018;25(2):231–236
Cysts are one of the most common lesions found in the stomatognathic system. Cysts cause not only bone defect but may also cause systemic complications.

Aim of the study was to investigate influence of odontogenic cysts on immune system.

Material and methods:
45 patients participated in the study. The study groups consisted of 15 patients with radicular cysts (IC) and 15 patients with dentigerous cysts (DC). The control group (C) consisted of 15 healthy patients. Blood, saliva and sacs of cysts were analysed with use of flow cytometry technique in order to asses number of T lymphocytes.

Results and discussion:
Ratio of T lymphocytes in blood and saliva differed between groups. Analysis of cyst’s sacs showed significantly higher number of T cells in radicular cysts.

The study has shown that odontogenic cysts have influence on immune system. T cells play important role in the process of odontogenic cysts’ development. Research stresses how important is fast detection and treatment of cysts, not only in term of local but also systemic complications.

All authors declare that there is no conflict of interest.
The study was funded by Medical University in Lublin.
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