Influence of odontogenic cysts on immune system – cytometric analysis of T lymphocytes subpopulation
More details
Hide details
Chair and Department of Oral Surgery, Medical University in Lublin, Poland
Department of Clinical Genetics, Medical University in Lublin, Poland
Submission date: 2016-09-23
Acceptance date: 2017-06-06
Online publication date: 2018-06-16
Publication date: 2019-11-18
Corresponding author
Rafał Jamrogiewicz   

Chair and Department of Oral Surgery, Medical University in Lublin, Karmelicka 7, 20-081 Lublin, Poland. Tel.: +4881 528 79 50, Fax: +4881 528 79 51.
Pol. Ann. Med. 2018;25(2):231-236
Cysts are one of the most common lesions found in the stomatognathic system. Cysts cause not only bone defect but may also cause systemic complications.

Aim of the study was to investigate influence of odontogenic cysts on immune system.

Material and methods:
45 patients participated in the study. The study groups consisted of 15 patients with radicular cysts (IC) and 15 patients with dentigerous cysts (DC). The control group (C) consisted of 15 healthy patients. Blood, saliva and sacs of cysts were analysed with use of flow cytometry technique in order to asses number of T lymphocytes.

Results and discussion:
Ratio of T lymphocytes in blood and saliva differed between groups. Analysis of cyst’s sacs showed significantly higher number of T cells in radicular cysts.

The study has shown that odontogenic cysts have influence on immune system. T cells play important role in the process of odontogenic cysts’ development. Research stresses how important is fast detection and treatment of cysts, not only in term of local but also systemic complications.

The study was funded by Medical University in Lublin.
All authors declare that there is no conflict of interest.
Elzay RP. Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol. 1982;54(3):299–303.
Tortorici S, Amodio E, Massenti MF, Buzzanca ML, Burruano F, Vitale F. Prevalence and distribution of odontogenic cysts in Sicily: 1986–2005. J Oral Sci. 2008;50(1):15–18.
Tegginamani AS, Prasad R. Histopathologic evaluation of follicular tissues associated with impacted lower third molars. J Oral Maxillofac Pathol. 2013;17(1):41–44.
Gondim JO, Neto JJ, Nogueira RL, Giro EM. Conservative management of dentigerous cyst secondary to primary tooth trauma. Dent Traumatology. 2008;24(6):676–679.
Fukada SY, Silva TA, Garlet GP, Rosa AL, da Silva JS, Cunha FQ. Factors involved in the T helper type 1 and type 2 cell commitment and osteoclast regulation in inflammatory apical diseases. Oral Microbiol Immunol. 2009;24(1):25–31.
Jankovic D, Liu Z, Gause WC. Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways. Trends Immunol. 2001;22(8):450–457.
Koc-Gąska M. Diagnostic pitfalls of tobacco smoking: The effect of nicotine addiction on the oral cavity – Literature review. Pol Ann Med. 2013;20(1):56–61.
Naiff PF, Ferraz R. unha CF, et al. Immunophenotyping in saliva as an alternative approach for evaluation of immunopathogenesis in chronic periodontitis. J Periodontol. 2014;85(5):111–120.
Kontiainen S, Ranta H, Lautenschlager I. Cells infiltrating human periapical inflammatory lesions. J Oral Pathol. 1986;15(10):544–546.
Matsuo T, Ebisu S, Shimabukuro Y, Ohtake T, Okada H. Quantitative analysis of immunocompetent cells in human periapical lesions: correlations with clinical findings of the involved teeth. J Endod. 1992;18(10):497–500.
Christodoulides N, Mohanty S, Miller CS, et al. Application of microchip assay system for the measurement of C-reactive protein in human saliva. Lab Chip. 2005;5(3):261–269.
Vidović A, Vidović Juras D, Vučićević Boras V, et al. Determination of leucocyte subsets in human saliva by flow cytometry. Arch Oral Biol. 2012;57(5):577–583.
Anil S, Shanavas KR, Beena VT, Remani P, Vijayakumar T. Quantitation of circulating immune complexes in patients with chronic periapical lesions. J Nihon Univ Sch Dent. 1993;35(3):175–178.
Okada H, Aono M, Yoshida M, Munemoto K, Nishida O, Yokomizo I. Experimental study on focal infection in rabbits by prolonged sensitization through dental pulp canals. Arch Oral Biol. 1967;12(9):1017–1034.
Journals System - logo
Scroll to top