REVIEW PAPER
Intima media thickness as an indicator of cardiovascular risk in hypertensive patients
More details
Hide details
1
Department of Allied Health Sciences, Faculty of Radiology Technology, Iqra University, Islamabad, Pakistan
2
Department of Radiological Sciences and Medical Imaging Technology, Ibadat International University, Islamabad, Pakistan
Submission date: 2024-07-30
Final revision date: 2025-02-14
Acceptance date: 2025-02-17
Online publication date: 2025-11-12
KEYWORDS
TOPICS
ABSTRACT
Introduction:
A key indicator of cardiovascular risk, especially in people with hypertension, is the carotid artery's intima-media thickness (IMT). This article focuses on how IMT and hypertension are related, how well IMT predicts cardiovascular events, and how antihypertensive medications affect the course of IMT.
Aim:
To search into the relationship between IMT and hypertension and evaluate how antihypertensive medication affects IMT in people with hypertension.
Material and methods:
A detailed analysis of the existing literature body served as the foundation for this investigation. Several electronic databases, including Embase, PubMed, Scopus, Web of Science, Cochrane Library, Frontiers, Taylor & Francis Online, Springer, and Elsevier, were searched systematically using pertinent keywords. Thirty articles were found to be eligible for review.
Results and discussion:
Increased IMT is closely linked to hypertension, suggesting that high blood pressure causes arterial wall thickening. Future cardiovascular events, including myocardial infarction and stroke, can be accurately predicted by elevated IMT. It has been demonstrated that antihypertensive medications, especially those that target the renin-angiotensin-aldosterone system, can effectively slow the progression of IMT. Improving patient outcomes requires early identification of subclinical atherosclerosis using IMT measurement and individualized treatment plans. To effectively manage hypertensive patients with elevated IMT, healthcare providers must work together.
Conclusions:
Reducing cardiovascular risk in hypertensive patients requires a multidisciplinary approach. Frequent IMT evaluation is useful for treatment planning and cardiovascular risk assessment. Furthermore, anesthesia professionals are essential to maintaining patient safety and maximizing pain control.
FUNDING
CONFLICT OF INTEREST
REFERENCES (25)
1.
Olmastroni E, Baragetti A, Casula M, et al. Multilevel models to estimate carotid intima-media thickness curves for individual cardiovascular risk evaluation. Stroke. 2019;50(7):1758–1765.
https://doi.org/10.1161/stroke....
2.
Chiesa ST, Charakida M, Georgiopoulos G, et al. Determinants of intima-media thickness in the young. JACC Cardiovasc Imaging. 2021;14(2):468–478.
https://doi.org/10.1016/j.jcmg....
3.
Zhang L, Fan F, Qi L, et al. The association between carotid intima-media thickness and new-onset hypertension in a Chinese community-based population. BMC Cardiovasc Disord. 2019;19(1):269.
https://doi.org/10.1186/s12872....
4.
Martire MV, Cipolletta E, Di Matteo A, et al. Is the intima-media thickness of temporal and axillary arteries influenced by cardiovascular risk? Rheumatology. 2021;60(11):5362–5368.
https://doi.org/10.1093/rheuma....
5.
Fernández-Alvarez V, Linares Sánchez M, López Alvarez F, et al. Evaluation of intima-media thickness and arterial stiffness as early ultrasound biomarkers of carotid artery atherosclerosis. Cardiol Ther. 2022;11(2):231–247.
https://doi.org/10.1007/s40119....
6.
Nwabuo CC, Yano Y, Moreira HT, et al. Long-term blood pressure variability in young adulthood and coronary artery calcium and carotid intima-media thickness in midlife. Hypertension. 2020;76(2):404–409.
https://doi.org/10.1161/hypert....
7.
Basirat M, et al. Risk factors and serum parameters associated with xerostomia in cardiac patients—a case-control study. Pol Ann Med. 2023;30(2):124–129.
https://doi.org/10.29089/paom/....
8.
Suzuki T, Wang W, Wilsdon A, et al. Carotid intima-media thickness and the risk of sudden cardiac death: The ARIC study and the CHS. J Am Heart Assoc. 2020;9(19).
https://doi.org/10.1161/jaha.1....
9.
Zheng H, Li H, Wang Y, et al. Rosuvastatin slows progression of carotid intima-media thickness: The METEOR-China randomized controlled study. Stroke. 2022;53(10):3004–3013.
https://doi.org/10.1161/stroke....
10.
Bolleke E, Likaj E, Seferi S, et al. Case Report Combined right and left sided endocarditis in a hemodialysis patient: A cautionary tale Polish Annals of Medicine. Pol Ann Med. 2024;31(1):17–20.
https://doi.org/10.29089/paom/....
11.
Cecelja M, Sriswan R, Kulkarni B, Kinra S, Nitsch D. Association of pulse wave velocity and intima-media thickness with cardiovascular risk factors in young adults. J Clin Hypertens. 2020;22(2):174–184.
https://doi.org/10.1111/jch.13....
12.
Oguanobi NI, Ejim EC, Anisiuba BC, Onwubere BJC, Ike SO, Ibegbulam OG. Echocardiographic findings in adult Nigerian sickle cell patients with cardiovascular autonomic dysfunction. Pol Ann Med. 2015;22(2):86–91.
https://doi.org/10.1016/j.poam....
13.
Drole Torkar A, Plesnik E, Groselj U, Battelino T, Kotnik P. Carotid intima-media thickness in healthy children and adolescents: Normative data and systematic literature review. Front Cardiovasc Med. 2020;7.
https://doi.org/10.3389/fcvm.2....
14.
Di Yacovo S, Saumoy M, Sánchez-Quesada JL, et al. Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study. PLoS One. 2020;15(8):e0237739.
https://doi.org/10.1371/journa....
16.
Vargas-Uricoechea H, Cáceres-Acosta MF. Control of blood pressure and cardiovascular outcomes in type 2 diabetes. Open Med. 2018;13(1):304–323.
https://doi.org/10.1515/med-20....
17.
Cermakova P, Ding J, Osorio Meirelles, et al. Carotid intima-media thickness and markers of brain health in a biracial middle-aged cohort: CARDIA brain MRI sub-study. J Gerontol A Biol Sci Med Sci. 2019;75(2):380–386.
https://doi.org/10.1093/gerona....
18.
Gromadziński L, Żelazny P, Żechowicz M, et al. Diffuse cerebral embolism as the first manifestation of the right atrial myxoma. Pol Ann Med. 2015;22(2):136–138.
https://doi.org/10.1016/j.poam....
19.
Williams B, Mancia G, Spiering W. 2018 ESC/ESH guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021–3104.
https://doi.org/10.1093/eurhea....
20.
Malarkiewicz E, Opalska A, Wojno D. Takotsubo cardiomyopathy or “broken heart syndrome” – A case report. Pol Ann Med. 2013;20(2):128–131.
https://doi.org/10.1016/j.poam....
21.
Anghel D, Sîrbu CA, Hoinoiu E-M, et al. Influence of anti-TNF therapy and homocysteine level on carotid intima-media thickness in rheumatoid arthritis patients. Exp Ther Med. 2021;23(1).
https://doi.org/10.3892/etm.20....
22.
Frigerio B, Werba JP, Amato M, et al. Traditional risk factors are causally related to carotid intima-media thickness progression: Inferences from observational cohort studies and interventional trials. Curr Pharm Des. 2020;26(1):11–24.
https://doi.org/10.2174/138161....
24.
Hensley B, Huang C, Cruz Martinez CV, Shokoohi H, Liteplo A. Ultrasound measurement of carotid intima–media thickness and plaques in predicting coronary artery disease. Ultrasound Med Biol. 2020;46(7):1608–1613.
https://doi.org/10.1016/j.ultr....
25.
Tan BYQ, Chew NWS, Lee GKH, et al. Psychological Impact of the COVID-19 Pandemic on Health Care Workers in Singapore. Ann Intern Med. 2020;173(4):317–320.
https://doi.org/10.7326/M20-10....