Introduction:
Amyloidosis is a disease characterized by the deposition of misfolded proteins in tissues, which aggregate into insoluble fibrils, leading to progressive organ damage. It presents with a wide spectrum of clinical manifestations depending on the location. Localized amyloidosis of the uterine cervix is exceedingly rare and may pose diagnostic challenges. Gynecological amyloidosis can be asymptomatic or present with symptoms such as abdominal pain, postmenopausal bleeding, or menorrhagia.

Aim:
This case report aims to highlight the occurrence of amyloidosis in gynecological practice and to describe the clinical, radiological, and histopathological features, along with the management approach leading to successful treatment.

Case study:
We report the case of a 52-year-old woman who presented with isolated abdominal pain. Transvaginal ultrasonography revealed a tumor at the cervico-uterine junction. A biopsy confirmed the diagnosis of localized cervical amyloidosis. Systemic involvement was excluded following whole-body radiological evaluation.

Results and discussion:
Laparotomy with radical hysterectomy and bilateral adnexectomy was conducted. Complete excision of the amyloid deposits was achieved without complications. Surgical treatment successfully alleviated the presenting symptoms.

Conclusions:
Localized amyloidosis of the uterine cervix represents a distinct clinical entity. Early diagnosis is crucial for effective management and symptom resolution. Surgical excision remains the preferred treatment for localized amyloidosis in gynecological sites, with histopathological confirmation required for diagnosis. This case underscores the importance of considering amyloidosis in the differential diagnosis of unusual gynecological presentations.