Myeloid sarcoma (chloroma) a rare tumour of the chest wall
More details
Hide details
Dietrich-Bonhoeffer-Klinikum, Neubrandenburg, Germany
Department of Thoracic Surgery and Transplantation, Pomeranian Medical University in Szczecin, Poland
Department of Pathology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland
Submission date: 2022-02-07
Final revision date: 2022-03-26
Acceptance date: 2022-03-27
Online publication date: 2022-05-20
Corresponding author
Seweryn Adam Skrzyniarz   

Dietrich-Bonhoeffer-Klinikum, Neubrandenburg, Germany
Pol. Ann. Med. 2023;30(1):63-67
Myeloid sarcoma (previously chloroma or granulocytic sarcoma) is a very rare malignant neoplasm associated with myeloproliferative neoplasms. This type of tumour can be located anywhere outside the bone marrow.

To describe the successful treatment and diagnostic of myeloid sarcoma.

Case study:
Retrospective case review.

Results and discussion:
This paper presents a case of myeloid sarcoma in a 50-year-old male. Patient presented due to pain lasting for 2 months in the left anterior axillary line region and a rapidly growing nodular lesion on the anterior chest wall. The lesion involved an extensive area of the ribs, causing rib destruction. Surgery was performed causing patients relief and chance of collecting histopathological tissue.

In myeloid sarcoma patients, surgical treatment does not only bring relief in symptomatic patients but also provides material for histopathological examination, which is necessary to confirm the diagnosis. An important part of the diagnosis is the implementation of a wide panel of immunohistochemical tests.

The authors received no financial support for the research, authorship and/or publication of this article.
The authors declare that they have no conflict of interest.
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A. Myeloid Sarcoma: Presentation, Diagnosis, and Treatment. Clin Lymphoma Myeloma Leuk. 2017;17(5):263–267.
Singh A, Kumar P Chandrashekhara SH, Kumar A. Unravelling chloroma: review of imaging findings. Br J Radiol. 2017;90(1075):20160710.
Shallis RM, Gale RP, Lazarus HM, Roberts KB, Xu ML, Seropian SE, Gore SD, Podoltsev NA. Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved. Blood Rev. 2020;30:100773.
Campidelli C, Agostinelli C, Stitson R, Pileri SA. Myeloid sarcoma: extramedullary manifestation of myeloid disorders. Am J Clin Pathol. 2009;132(3):426–437.
Claerhout H, Van Aelst S, Melis C, et al. Clinicopathological characteristics of de novo and secondary myeloid sarcoma: A monocentric retrospective study. Eur J Haematol. 2018;100(6):603–612.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M. Myeloid Sarcoma. Oncol Res Treat. 2019;42(4):224–229.
Takahashi M, Matsukura T, Hirai T, Mino N. Surgical resection for isolated myeloid sarcoma arising from a rib. Ann Thorac Surg. 2012;94(5):e117-8.
Raucci A, Fontanarosa A, Somma P, Bergaminelli C, Valente T, Rea G. Myeloid sarcoma of rib: An atypical isolated chest finding. Egyptian J Radiol Nucl Med. 2015; 46(1):105–109.
Guermazi A, Feger C, Rousselot P, et al. Granulocytic sarcoma (chloroma): imaging findings in adults and children. AJR Am J Roentgenol. 2002;178(2):319–325.
Hermann G, Feldman F, Abdelwahab IF, Klein MJ. Skeletal manifestations of granulocytic sarcoma (chloroma). Skeletal Radiol. 1991;20(7):509–512.
Liu PI, Ishimaru T, McGregor DH, Okada H, Steer A. Autopsy study of granulocytic sarcoma (chloroma) in patients with myelogenous leukemia, Hiroshima-Nagasaki 1949-1969. Cancer. 1973;31(4):948–955.
Pomeranz SJ, Hawkins HH, Towbin R, Lisberg WN, Clark RA. Granulocytic sarcoma (chloroma): CT manifestations. Radiology. 1985;155(1):167–170.
Wang W, He H, Chen X, Zhang C. Primary bronchial myeloid sarcoma mimicking bronchogenic carcinoma: a case report. BMC Pulm Med. 2019;19(1):204.
Pileri SA, Ascani S, Cox MC, et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 2007;21(2):340–350.
Ptaszyński K, Szumera-Ciećkiewicz A, Pekul M, Nowecki Z. Differential diagnosis of small round cell tumours (SRCT), fluorescence in situ hybridization (FISH) and immunohistochemical (IHC) study. Pol J Pathol. 2009;60(4):151–162.
Misiukiewicz-Poć M, Poniatowska-Broniek G, Gizelbach-Żochowska K, et al. Isolated primary myeloid sarcoma of small intestine – A case report and review of the literature. Pol Ann Med. 2012;19(2):122–128.
Yook HJ, Son JH, Kim YH, et al. Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients. Acta Derm Venereol. 202;102:adv00647.
Journals System - logo
Scroll to top