Review of intervertebral hernia disease treatment methodologies: Key emphasis on the oxygen-ozone therapy as a method with multifactorial influence
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Department of Physical and Rehabilitation Medicine of National Pirogov Memorial Medical University, University Clinic of National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Berkshire Medical Center, Pittsfield, MA, USA
Department of Physical and Rehabilitation Medicine of National Pirogov Memorial Medical University, Ukraine
Scientific and Research Institute of Invalid Rehabilitation (Educational, Scientific Treatment Complex) of National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Department of Internal Medicine of National Pirogov Memorial Medical University, Ukraine
University Clinic of National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Iryna V Baranova   

Department of Physical and Rehabilitation Medicine of National Pirogov Memorial Medical University, University Clinic of National Pirogov Memorial Medical University, Vinnytsya, Ukraine.
Submission date: 2021-05-30
Final revision date: 2021-11-28
Acceptance date: 2021-11-29
Online publication date: 2022-05-20
Low back pain is one of the most common causes of short-term, and sometimes long-term, disability in the population younger than 45 years old. Approximately 60% to 80% of the population in developed countries experience back pain in various locations (neck, mid and lower back) at least once in their lifetime. Guidelines regarding back pain treatment are undergoing constant modifications and improvements. The relevance of dorsalgia as a significant medical problem and its management is shown by the increased number of recently published papers, which has tripled in the past several years (from 22% to 65%).

To analyze the most critical risk factors of the degenerative intervertebral disk disease, and to review the effectiveness of invasive and noninvasive methods of treatment of the lower back pain syndrome.

Material and methods:
Recently published papers focusing on invasive and noninvasive treatments of low back pain syndrome.

Results and discussion:
Surgical intervention as a single method of back pain treatment is indicated in a small number of cases. The risk of repeated surgeries for intravertebral disk herniation should be considered before any surgical intervention. A wide variety of treatment options allows to choose the most effective approach based on individual needs.

Conservative, noninvasive approach has shown to be an effective alternative for lower back pain and radiculopathy treatment. It has been determined that ozone therapy is an appropriate, relevant, and affordable treatment method for patients with vertebral degenerative changes and intravertebral disk diseases.

We thank our colleagus from National Pirogov Memorial Medical University (Vinnytsya, Ukraine) for help in collection materials during preparing the manuscript.
This research was not sponsored by any foundations or organizations.
Authors declare no conflict of interest.
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