Risk factors and serum parameters associated with xerostomia in cardiac patients – a case-control study
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Dental Sciences Research Center, Medical Education Research Center, Department of Oral and Maxillofaicial Medicine, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
Cardiovascular Disease Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
General dentist, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Alborz University of Medical Sciences, Karaj, Iran
Submission date: 2023-04-14
Final revision date: 2023-11-11
Acceptance date: 2023-11-11
Online publication date: 2023-12-01
Corresponding author
Fereshteh Najar Karimi   

Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Alborz University of Medical Sciences, Shahid katouiezade st., Golshahr avenue, karaj, Iran. Postal code: 3198684868. Tel.: +26 3350 0080.
Pol. Ann. Med. 2023;30(2):124-129
Xerostomia is not a disease in itself but is caused by a change in the amount or composition of saliva or both. Some systemic diseases and the use of some medicines cause this complaint.

Considering the high prevalence of cardiac diseases, the present study aimed to examine risk factors and serum parameters associated with xerostomia among hospitalized cardiac patients.

Material and methods:
In this case-control study, 369 hospitalized cardiac patients were divided into two groups (with and without xerostomia) using a valid FOX questionnaire. Demographic information and laboratory analysis results were extracted from the subjects’ medical records. Finally, data were analyzed using SPSS v. 24 software at a significance level of 0.05.

Results and discussion:
According to the findings, 187 (50.7%) patients were suffering from xerostomia, whose prevalence was significantly higher in patients with a history of hypertension (P = 0.017) and thrombocytosis (P = 0.023). However, no significant relationship was observed between xerostomia and other serum parameters.

Xerostomia is associated with a history of hypertension and the use of certain medications, such as nitroglycerin. Other serum parameters seem to be unrelated to xerostomia, except thrombocytosis. Therefore, it is recommended to check the quantity and quality of saliva to evaluate the presence of hyposalivation along with xerostomia more accurately.

The authors would like to thank Dr. Rasoul Tabari Khomeiran for his helpful comments and Dr Mohammad Ghaffari for performing statistical analysis throughout the paper.
No external funding was available for this study.
According to the authors of this article, there is no conflict of interests.
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