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RESEARCH PAPER
Correlation of body mass index with serum total PSA, total testosterone and prostatic volume in a sample of men
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Urology Department, Alexandria University, Alexandria, Egypt
CORRESPONDING AUTHOR
Ahmed Fouad Kotb   

Faculty of Medicine, Azarita, Sultan Hussein Street, Alexandria, Egypt. Tel.: +20 34860029; mobile: +20 1203021316.
Submission date: 2015-05-09
Acceptance date: 2015-07-08
Online publication date: 2015-08-21
Publication date: 2020-03-23
 
Pol. Ann. Med. 2016;23(1):1–5
DOI: https://doi.org/10.1016/j.poamed.2015.07.001
 
 
Article (PDF)
References (39)
 
KEYWORDS
body mass index
PSA
testosterone
prostate
 
ABSTRACT
Introduction:
The prevalence of both obesity and prostate cancer are increasing worldwide.

Aim:
The aim of this study was to correlate BMI with serum total PSA, serum total testosterone and prostatic volume.

Material and methods:
This study was conducted on 100 consecutive male patients aged ≥ 50 years old recruited from the Urogenital Surgery outpatient clinic. Exclusion criteria were history of previously diagnosed or treated cancer prostate, the use of 5-a-reductase inhibitors and patients with serum PSA ≥10 ng/mL.

Results and discussion:
The mean age of patients was 57.5 ± 5.4 years (range: 50–72). The mean BMI was 33.1 ± 6.5 kg/m2, (range: 23.7–51.3). The mean serum PSA was 4.1 ± 0.8 ng/mL (range: 0.9–5.4). The mean serum testosterone was 4.6 ± 2.2 nmol/L (range: 0.8–9.8). The mean prostate volume was 54 ± 14 cm3 (range: 19–90). Higher BMI was significantly associated with a lower serum PSA, testosterone and higher prostate volume (P < 0.05 for all factors).

Conclusions:
Patients with higher body mass index are more liable to have lower serum total PSA, lower serum total testosterone and higher prostate volume. Obesity may be associated with hormonal independent growth of prostatic tissues.

CONFLICT OF INTEREST
None declared.
 
REFERENCES (39)
1.
Skolarus TA, Wolin KY, Grubb RL. The effect of body mass index on PSA, prostate cancer development and treatment. Nat Clin Pract Urol. 2007;4:605–614.
Google Scholar
 
 
2.
Calle EE, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N Engl J Med. 2003;348:1625–1638.
Google Scholar
 
 
3.
Mosteller RD. Simplified calculation of body surface area. N Engl J Med. 1987;317:1098.
Google Scholar
 
 
4.
Laffin RJ, Chan DW, Tanasijevic MJ, et al. Hybritech total and free prostate-specific antigen assays developed fo the Beckman Coulter access automated chemiluminescent immunoassay system: a multicenter evaluation of analytical performance. Clin Chem. 2001;47:129–132.
Google Scholar
 
 
5.
Van Uytfanghe K, Stockl D, Kaufman JM, et al. Validation of 5 routine assays for serum free testosterone with a candidate reference measurement procedure based on ultrafiltration and isotope dilution–gas chromatography–mas spectrometry. Clin Biochem. 2005;38:253–261.
Google Scholar
 
 
6.
Hanash KA, Al-Othmaimen A, Kattan S, et al. Prostatic carcinoma. A nutritional disease? Conflicting data from the Kingdom of Saudi Arabia. J Urol. 1999;161:71.
Google Scholar
 
 
7.
Kehinde EO, Mojiminiyi OA, Sheikh M, et al. Age-specific reference levels of serum prostate-specific antigen and prostate volume in healthy Arab men. Br J Urol. 2005;96:308–312.
Google Scholar
 
 
8.
Hekal IA, Ibrahiem El.. Obesity–PSA relationship: a new formula. Prostate Cancer Prostatic Dis. 2010;13:186–190.
Google Scholar
 
 
9.
Kim GW, Doo SW, Yang WJ, et al. Effects of obesity on prostate volume and lower urinary tract symptoms in Korean men. Korean J Urol. 2010;51:344–347.
Google Scholar
 
 
10.
Price MM, Hamilton RJ, Robertson CN, et al. Body mass index, prostate-specific antigen, and digital rectal examination findings among participants in a prostate cancer screening clinic. Urology. 2008;71:787–791.
Google Scholar
 
 
11.
Baillargeon J, Pollock BH, Kristal AR, et al. The association of body mass index and prostate-specific antigen in a population-based study. Cancer. 2005;103:1092–1095.
Google Scholar
 
 
12.
Hutterer G, Perrotte P, Gallina A, et al. Body mass index does not predict prostate-specific antigen or percent free prostate-specific antigen in men undergoing prostate cancer screening. Eur J Cancer. 2007;43:1180–1187.
Google Scholar
 
 
13.
Freedland SJ, Platz EA, Presti Jr JC et al. Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection. J Urol. 2006;175:500–504.
Google Scholar
 
 
14.
Loeb S, Yu X, Nadler RB, et al. Does body mass index affect preoperative prostate specific antigen velocity or pathological outcomes after radical prostatectomy? J Urol. 2007;177:102–106.
Google Scholar
 
 
15.
Parsons JK, Sarma AV, McVary K, et al. Obesity and benign prostatic hyperplasia: clinical connections, emerging etiological paradigms and future directions. J Urol. 2009;182:S27–S31.
Google Scholar
 
 
16.
MacDonald AA, Herbison GP, Showell M, et al. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update. 2010;16:293–311.
Google Scholar
 
 
17.
Pasquali R, Patton L, Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes. 2007;14:482–487.
Google Scholar
 
 
18.
Schneider G, Kirschner MA, Berkowitz R, et al. Increased estrogen production in obese men. J Clin Endocrinol Metab. 1979;48:633–638.
Google Scholar
 
 
19.
Akingbemi BT. Estrogen regulation of testicular function. Reprod Biol Endocrinol. 2005;3:51.
Google Scholar
 
 
20.
de Boer H, Verschoor L, Ruinemans-Koerts J, et al. Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism. Diabetes Obes Metab. 2005;7:211–215.
Google Scholar
 
 
21.
Dhindsa S, Furlanetto R, Vora M, et al. Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes. Diabetes Care. 2011;34:1854–1859.
Google Scholar
 
 
22.
Hammoud A, Carrell DT, Meikle AW. An aromatase polymorphism modulates the relationship between weight and estradiol levels in obese men. Fertil Steril. 2010;94:1734–1738.
Google Scholar
 
 
23.
Hammoud AO, Griffin J, Meikle AW, et al. Association of aromatase (TTTAn) repeat polymorphism length and relationship between obesity and decreased sperm concentration. Hum Reprod. 2010;25:3146–3151.
Google Scholar
 
 
24.
Vermeulen A, Kaufman JM, Deslypere JP, et al. Attenuated leuteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab. 1993;76:1140–1146.
Google Scholar
 
 
25.
Blank DM, Clark RV, Heymsfield SB, et al. Endogenous opioids and hypogonadism in human obesity. Brain Res Bull. 1994;34:571–574.
Google Scholar
 
 
26.
Dandona P, Dhindsa S. Update: hypogonadotropic hypogonadism in type 2 diabetes and obesity. J Clin Endocrinol Metab. 2011;96:2643–2651.
Google Scholar
 
 
27.
Luboshitzky R, Lavie L, Shen-Orr Z, et al. Altered luteinizing hormone and testosterone secretion in middle-aged obese men with obstructive sleep apnea. Obes Res. 2005;13:780–786.
Google Scholar
 
 
28.
Luboshitzky R, Zabari Z, Shen-Orr Z, et al. Disruption of the nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab. 2001;86:1134–1139.
Google Scholar
 
 
29.
Hammoud AO, Walker JM, Gibson M. Sleep Apnea, reproductive hormones and quality of sexual life in severely obese men. Obesity. 2011;19:1118–1123.
Google Scholar
 
 
30.
Axelsson J, Ingre M, Akerstedt T, et al. Effects of acutely displaced sleep on testosterone. J Clin Endocrinol Metab. 2005;90:4530–4535.
Google Scholar
 
 
31.
Boyar RM, Rosenfeld RS, Kapen S. Human puberty: simultaneous secretion of luteinizing hormone and testosterone during sleep. J Clin Invest. 1974;54:609–618.
Google Scholar
 
 
32.
Schiavi RC, White D, Madeli J. Pituitary-gonadal function during sleep in healthy aging men. Psychoneuroendocrinology. 1992;17:599–609.
Google Scholar
 
 
33.
Stellato RK, Feldman HA, Hamdy O, et al. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care. 2000;23:490–494.
Google Scholar
 
 
34.
Tsai EC, Matsumoto AM, Fujimoto WY, et al. Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care. 2004;27:861–868.
Google Scholar
 
 
35.
Goyal HO, Robateau A, Braden TD, et al. Neonatal estrogen exposure of male rats alters reproductive functions at adulthood. Biol Reprod. 2003;68:2081–2091.
Google Scholar
 
 
36.
Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risk of male infertility. Hum Reprod. 2001;16:1768–1776.
Google Scholar
 
 
37.
Jimenez Torres M, Campoy Folgoso C, Canabate Rache F. Organochlorine pesticides in serum and adipose tissue of pregnant women in Southern Spain giving birth by Cesarean section. Sci Total Environ. 2006;372:32–38.
Google Scholar
 
 
38.
Momen MN, Fahmy I, Amer M, et al. Semen parameters in men with spinal cord injury: changes and aetiology. Asian J Androl. 2007;9:684–689.
Google Scholar
 
 
39.
Blomberg Jensen M, Bjerrum PJ, Jessen TE. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod. 2011;26:1307–1317.
Google Scholar
 
 
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