New method in assessment of blood plasma coagulation balance
Oleksiy Storozhuk 1  
,   Larysa Storozhuk 2  
,   Tetyana Dovgalyuk 2  
,   Nadiya Storozhuk 3  
,   Natalya Androsova 4  
,   Borys Storozhuk 3  
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Department of Physical Education and Physical Therapy, National Pirogov Memorial Medical University, Vinnytsia, Ukraine
Research Institute of Rehabilitation of National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Department of Internal Medicine No 3, National Pirogov Memorial Medical University, Vinnytsia, Ukraine
Vinnytsia Regional Center of Medical and Social Examination, Vinnytsia, Ukraine
Borys Storozhuk   

Department of Internal Medicine No 3, National Pirogov Memorial Medical University, 56 Street Pirogova, Vinnytsia, Ukraine. Tel.: +38 050-313-3302
Submission date: 2021-02-18
Final revision date: 2021-03-30
Acceptance date: 2021-03-30
Online publication date: 2021-10-20
Thrombotic complications associated with disorders of hemostatic system are quite common among various categories of patients and require timely objective assessment of coagulation balance.

To develop an integrated index of assessment of blood plasma coagulation balance using the method of ‘overall haemostasis potential,’ and to test its practical value in clinical settings.

Material and methods:
179 patients were studied: 88 with chronic kidney disease (CKD) of VD stage, treated by program hemodialysis, and 91 with ischemic heart disease (IHD) after percutaneous transluminal coronary angioplasty (PTСA). The state of overall coagulation and fibrinolytic potentials was studied in all patients using the method of overall hemostasis potential (OHP). Based on this method, coagulation index (CI) was calculated and tested in such categories of patients.

Results and discussion:
Patients with stage VD CKD demonstrated the tendency to hypocoagulation, while those with coronary heart disease (CHD) and PTСA – significant hypercoagulation, being indicated by CI index.

Patients with stage VD CKD have the tendency to hypocoagulation, while those with CHD and PTСA – to hypercoagulation. The integrated index suggested for assessment of coagulation potential – coagulation index – can adequately reflect coagulation balance disorders and considerably simplify their quantitative assessment.

The study was conducted as a part of research work ‘To determine the role of pro- and anticoagulant factors of hemostasis and coagulation potential parameters in the development of comorbid conditions in patients with chronic kidney disease VD stage and to develop the criteria for thrombophilia prevention,’ financed by the Ministry of Health of Ukraine at the state budget expense, state registration number 0119U101156.
The authors declare no conflict of interest.
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