Phoenixin plasma concentration in heart failure with reduced ejection fraction patients
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Anesthesiology, Intensive Care and Emergency Medicine Department, Collegium Medicum, University of Zielona Gora, Poland
Research and Development Center, Regional Specialist Hospital, Wroclaw, Poland
Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
1st Department of Cardiology, Poznan University of Medical Sciences, Poland
Submission date: 2022-03-08
Final revision date: 2022-05-30
Acceptance date: 2022-05-30
Online publication date: 2022-10-05
Corresponding author
Tomasz Zemleduch   

Anesthesiology, Intensive Care and Emergency Medicine Department, Collegium Medicum, University of Zielona Gora, Zyty 28, 65-046 Zielona Góra, Poland. Tel.: +48 607 162 333.
Pol. Ann. Med. 2023;30(1):31-37
Heart failure (HF) nowadays in western countries is an immense problem largely due to its social impact as well as an economic burden. A widely accepted biomarker-based strategy to establish prognosis and predict re-hospitalization events in HF is lacking. Currently, besides natriuretic peptides and cardiac troponins, a variety of molecules are being studied. Phoenixin (PNX) is a neuropeptide mainly involved in the regulation of gonadotropin secretion. Recently, a significant cardioprotective effect of PNX was reported.

The aim of this study was to measure PNX plasma concentration in a group of HF with reduced ejection fraction (HFrEF) patients and to compare it to levels found in HF-negative participants.

Material and methods:
A group of 74 HFrEF patients and a control group consisting of 40 participants without systolic or diastolic myocardial dysfunction were studied. Each individual underwent anthropometric measurements, laboratory testing, clinical and echocardiographic examination. To evaluate PNX plasma concentration, an immunoenzymatic assay (ELISA) was performed.

Results and discussion:
PNX plasma concentration in the HFrEF group was not statistically different than in the control group. No significant correlation between PNX level and age, sex, BMI, HF etiology, diabetes or atrial fibrillation presence was found. PNX concentration correlated positively with total and LDL cholesterol blood levels in HFrEF patients. A negative correlation was found with creatinine in HFrEF, uric acid and triglycerides levels as well as AlAT activity in the control group.

There is no significant difference in PNX plasma concentration between HF and non-HF individuals. PNX role in cardiovascular disease requires further investigation.

Project supported by Wroclaw Centre of Biotechnology, The Leading National Research Centre (KNOW) programme for years 2014–2018, no. W1/1/4/2018.
None declared.
Polish Central Statistical Office: Accessed: 16.09.2022.
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