The association between blood cadmium levels and the risk of gastrointestinal cancer in Tabriz, northwest of Iran
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Nutrition Research Center, Student Research Committee, Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Nutrition Research Center, Student Research Committee, Department of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Epidemiology, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Submission date: 2016-01-09
Acceptance date: 2016-05-11
Online publication date: 2016-08-23
Publication date: 2019-12-19
Pol. Ann. Med. 2017;24(2):133-137
Cancer is amajor health problem worldwide. Gastrointestinal tract malignancy is one of the most common forms of cancer around the world. Occupational exposure to the heavy metals including cadmium was defined as one of the most important environmental risk factors involved in initiation of cancer. Cadmium, a toxic and non-essential heavy metal, was classified as group 1 carcinogen.

The aim of this study was to investigate the association between blood cadmium levels and the risk of gastrointestinal cancer in cancer patients.

Material and methods:
This descriptive study was carried out on 111 [42TD$DIF]gastrointestinal cancer patients as cases and 111 healthy people as controls from January to October 2013 in Tabriz, northwest of Iran. The protocol of this study is approved by the Ethics Committee in Tabriz University of Medical Science. Considering inclusion criteria, participants were selected randomly and a written informed consent was filled out for each patient. Demographic datawere obtained by questionnaire. Blood samples (5 mL) were collected from each patient in fasting status and analyzed by graphite furnace atomic absorption spectrophotometer (GFAAS).

Results and discussion:
Blood cadmium levels were significantly higher in cancer patients compared to healthy individuals (P = 0.037). The results of multivariate regression model did not show significant association between the concentrations of blood cadmium and the risk of gastrointestinal cancer: P = 0.137, OR = 1.15 (95% CI; 0.96–1.38).

Our data suggest that finding individuals with high blood cadmium level and then lowering this amount can be considered as important strategy to prevent gastrointestinal cancer.

The authors thank the Vice Chancellor for Research (VCR) of Tabriz University of Medical Sciences (TUOMS), Nutrition Research Center and Department of Internal Medicine for supporting this study. This is a part of a database from thesis entitled “Evaluation of the dietary habits, urinary and blood cadmium of some gastrointestinal cancer patients with healthy people.”
There was no conflict of interest.
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