Therapeutic properties of lactoferrin
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Department of Animal Hygiene and Environmental, University of Warmia and Mazury in Olsztyn, Poland
Department of Clinical Physiology, University of Warmia and Mazury in Olsztyn, Poland
Department of Cattle Breeding and Milk Evaluation, University of Warmia and Mazury in Olsztyn, Poland
Department of General Surgery, Ysbyty Gwynedd Hospital, Bangor, United Kingdom
Submission date: 2017-03-19
Acceptance date: 2017-04-05
Online publication date: 2018-02-26
Publication date: 2019-11-18
Corresponding author
Jan Miciński   

Department of Cattle Breeding and Milk Evaluation, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5/150, 10-957 Olsztyn, Poland. Tel.: +4889 523 38 64. Fax: +4889 523 44 13.
Pol. Ann. Med. 2018;25(1):158-161
For many years, milk and colostrum proteins have been the object of scientists’ interest. A group of whey proteins, including lactoferrin (Lf) are credited with special features that promote health and wellbeing.

The purpose of this paper is to disseminate health and medical properties of lactoferrin originating from the cow’s milk and bovine ncolostrum.

Extensive research (clinical as well) proves that lactoferrin is beneficial for the human organism. Moreover, no harmful side-effects have been reported following its application. Effective antibacterial function against intestinal pathogenic bacteria and simultaneous stimulation of beneficial microflora are the main functions of this compound. Lactoferrin can also be used in management of cancer and numerous viral infections (i.e. herpes virus or rotavirus) as it stimulates the immune system.

In summary, lactoferrin is a milk protein increasingly more appreciated in medicine. Interest in this protein is rising, which is reflected in numerous scientific and clinical studies that underline its medical importance. Furthermore, research will surely contribute to the understanding of its function and ultimately, it will play a significant role on the market.

None declared.
Aimutis WR. Bioactive properties of milk proteins with particular focus on anticariogenesis. J Nutr. 2004;134(4):989S–995S.
Król J, Brodziak A, Litwińczuk Z, Szwajkowska M. [Whey protein utilization in health promotion]. Pol J Human Nutr Metabol. 2011;38(1):165–186 [in Polish].
Miciński J, Zwierzchowski G, Kowalski IM, Szarek J. Health – promoting propetries of selected milk components. J Elem. 2013;18(1):165–186.
Król J, Brodziak A. [Milk proteins with antibacterial properties]. Probl Hig Epidemiol. 2015;96(2):399–405 [in Polish].
Miciński J, Zwierzchowski G, Kowalski IM, Szarek J, Pierożyński B, Raistenskis J. The effect of bovine milk fat on human health. Pol Ann Med. 2012;19(2):170–175.
Zimecki M, Artym J. [Therapeutic properties of proteins and peptides from colostrum and milk]. Postepy Hig Med Dosw (Online). 2005;59:309–323 [in Polish].
Miciński J, Klupczyński J, Mordas W, Zabłotna R. Yield and composition of milk from Jersey cows as dependent on the genetic variants of milk proteins. Pol J Food Nutr Sci. 2007;57(3):95–99.
Zwierzchowski G, Miciński J, Górecka-Ordon E, Gocałwski P. Is food allergy a civilization – related disease? Pol Ann Med. 2011;18(1):168–176.
Miciński J, Kowalski I, Zwierzchowski G, Szarek J, Pierożyński J, Zabłocka E. Characteristics of cow’s milk proteins including allergenic properties and methods for its reduction. Pol Ann Med. 2013;20(1):69–76.
Król J, Brodziak A, Litwińczuk A. [Basic chemical composition and content of selected whey proteins in milk from different cow breeds and in rennet whey]. Żywność: Nauka, Technologia, Jakość. 2011;4(77):74–83 [in Polish].
Gapper LW, Copestake DE, Otter DE, Indyk HE. Analysis of bovine immunoglobulin G in milk, colostrum and dietary supplements: a review. Anal Bioanal Chem. 2007;389(1): 93–109.
Mojka K. [Characteristics of fermented milk drinks]. Probl Hig Epidemiol. 2013;94(4):722–729 [in Polish].
Rak KA, Bronkowska M. [Immunological role of colostrum]. Hygeia Public Health. 2014;49(2):249–254 [in Polish].
Diarra MS, Petitclerc D, Lacasse P. Effect of lactoferrin in combination with penicillin on the morphology and the physiology of Staphylococcus aureus isolated from bovine mastitis. J Dairy Sci. 2002;85(5):1141–1149.
Stelwagen K, Carpenter E, Haigh B, Hodgkinson A, Wheeler TT. Immune components of bovine colostrum and milk. J Anim Sci. 2009;87(13 Suppl):3–9.
Zander Z, Zander L, Mickiewicz D. [Lactoferrin – multipotential milk protein]. Innovative Dairy. 2014;2(1):18–21 [in Polish].
Gajda-Morszewski P, Śpiewak K. [Lactoferrin – a multipotential protein]. Zeszyty Naukowe Towarzystwa Doktorantów UJ Nauki Ścisłe. 2015;1(10):177–188 [in Polish].
Baker EN, Baker HM. Molecular structure, binding properties and dynamics of lactoferrin. Cell Mol Life Sci. 2005;62(22):2531–2539.
Yao X, Bunt C, Cornish J, Siew-Young Q, Jingyuan W. Improved RP-HPLC method for determination of bovine lactoferrin and its proteolytic degradation in simulated gastrointestinal fluids. Biomed Chromatogr. 2013;27(2):197–202.
Gajda-Morszewski P, Śpiewak K. [Medical applications of lactoferrin]. Zeszyty Naukowe Towarzystwa Doktorantów UJ Nauki Ścisłe. 2015;2(11):67–76 [in Polish].
Farnaud S, Evans RW. Lactoferrin – a multifunctional protein with antimicrobial properties. Mol Immunol. 2003;40(7):395–405.
Orsi N. The antimicrobial activity of lactoferrin: current status and perspectives. Biometals. 2004;17(3):189–196.
Minkiewicz P, Miciński J, Darewicz M, Bucholska J. Biological and Chemical Databases for Research into the Composition of Animal Source Foods. Food Revs Int. 2013;29:321–351.
Bellamy W, Takase M, Yamauchi K, Wakabayashi H, Kawase K, Tomita M. Identification of the Bactericidal Domain of Lactoferrin. Biochim Biophys Acta.1992;1121(1–2):130–136.
Liao Y, Jiang R, Lönnerdal B. Biochemical and molecular impacts of lactoferrin on small intestinal growth and development during early life. Biochem Cell Biol. 2012;90(3):476–484.
Actor JK, Hwang SA, Kruzel ML. Lactoferrin as a natural immune modulator. Curr Pharm Des. 2009;15(17):1956–1973.
Sánchez L, Calvo M, Brock JH. Biological role of lactoferrin. Arch Dis Child. 1992;67(5):657–661.
Małaczewska J, Rotkiewicz Z. Lactoferrin – a multipotential protein. Med Wet. 2007;63(2):136–139.
Wakabayashi H, Yamauchi K, Takase M. Lactoferrin research, technology and applications. Int Dairy J. 2006;16(11):1241–1251.
Bhimani RS, Vendrov Y, Furmanski P. Influence of lactoferrin feeding and injection against systemic staphylococcal infections in mice. J Appl Microbiol. 1999;86(1):135–144.
Håversen LA, Engberg I, Baltzer L, Dolphin G, Hanson LA, Mattsby-Baltzer I. Human lactoferrin and peptides derived from a surface-exposed helical region reduce experimental Escherichia coli urinary tract infection in mice. Infect Immun. 2000;68(10):5816–5823.
Trümpler U, Straub PW, Rosenmund A. Antibacterial prophylaxis with lactoferrin in neutropenic patients. Eur J Clin Microbiol Infect Dis. 1989;8(4):310–313.
van der Strate BW, Beljaars L, Molema G, Harmsen MC, Meijer DK. Antiviral activities of lactoferrin. Antiviral Res. 2001;52(3):225–239.
Andersen JH, Jenssen H, Gutteberg TJ. Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir. Antiviral Res. 2003;58(3):209–215.
Nozaki A, Tanaka K, Naganuma A, Kato N. [Recent advances of basic research and clinical application of lactoferrin as an antiviral reagent against chronic hepatitis C]. Nihon Rinsho. 2002;60(4):819–829 [in Japanese].
Eliassen LT, Berge G, Sveinbjørnsson B, Svendsen JS, Vorland LH, Rekdal Ø. Evidence for a direct antitumor mechanism of action of bovine lactoferricin. Anticancer Res. 2002;22(5):2703–2710.
Shimamura M, Yamamoto Y, Ashino H, et al. Bovine lactoferrin inhibits tumor-induced angiogenesis. Int J Cancer. 2004;111(1):111–116.
Zimecki M, Wieczorek Z, Mazurier J, Spik G. Lactoferrin lowers the incidence of positive Coombs’ test in New Zealand black mice. Arch Immunol Ther Exp (Warsz). 1995;43(3–4):207–209.
Hayashida K, Takeuchi T, Harada E. Lactoferrin enhances peripheral opioid-mediated antinociception via nitric oxide in rats. Eur J Pharmacol. 2004;484(2–3):175–181.
Narayana Raju KV, Ashok Kumar D, Arutselvan N, Thejomoorthy P, Puvanakrishnan R. Antinociceptive and antipyretic effects of a derivatized tetrapeptide from lactoferrin in rats. Peptides. 2005;26(4):615–619.
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