Properties of bovine colostrum and the possibilities of use
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Department of Animal Hygiene and Environmental, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Poland
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland
Department of Technology of Livestock Products, National Agrarian University in Kostanay, Kazakhstan
Department of Cattle Breeding and Milk Evaluation, Faculty of Animal Bioengineering, University of Warmia and Mazury in Olsztyn, Poland
Department of Technology and Biological Resources, Kazakh National Agrarian University in Almaty, Kazakhstan
Department of Rehabilitation, Faculty of Medicine Sciences, University of Warmia and Mazury in Olsztyn, Poland
Jan Miciński   

Department of Cattle Breeding and Milk Evaluation, Faculty of Animal Bioengineering, University of Warmia and Masury in Olsztyn, Oczapowskiego 5/150, 10-957 Olsztyn, Poland.
Submission date: 2017-01-12
Acceptance date: 2017-03-28
Online publication date: 2017-07-04
Publication date: 2020-03-22
Pol. Ann. Med. 2017;24(2):295–299
Food manufacturers compete on the market, introducing innovative products. Functional products, which show a beneficial impact on human health over the one which comes from the basic product component, are becoming increasingly important. Since a few years researchers underline a huge importance of colostrum in this trade. 'First milk' is significantly richer in biologically active peptides, immunologic components and growth factors than later milk.

In the article an overview of literature concerning the meaning of bovine colostrum in human nutrition and its therapeutic properties was performed.

A vast research which was conducted on animals, as well as in strict laboratory conditions (in vitro, in vivo) confirm clinical benefits of colostrum. A number of analyses is still conducted, which additionally refer to the design of the appropriate dose and time of treatment with colostrum. Colostrum is considered a fully safe substance. To this moment, even with very high doses, very few side effects were noted. The main functions of the colostrum are supplying the organism with essential nutrients which strengthen the immune system, stimulation of the immune system response, maintaining the intestinal microflora and tissue regeneration acceleration.

Summing up, further use of products based on colostrum both in healthy individuals – prevention, as well as with some diseases is justified. The interest in questioned substance is rising due to vast scientific and clinical research underlining the significance of colostrum in feeding of human beings. Scientists predict that products based on colostrum may play a significant role on the functional products market in the future.

We would like to express our gratitude to Radoslaw Mikolajski for assistance in translation of the article.
None declared.
Mendar K. Market and marketing of functional food in Europe. J Food Eng. 2003;56(2–3):181–188.
Hirai S, Takashashi N, Goto T, et al. Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies. Mediat Inflamm. 2010;17(1):4–12.
Kudełka W. Innovative food segment supporting human health. Przem Spoż. 2011;18:290–302 [in Polish].
Chetthamrongchai P, Davies G. Segmenting the market for food shoppers using attitudes to shopping and to time. Br Food J. 2000;102(2):81–101.
Siró I, Kápolna E, Kápolna B, Lugasi A. Product development, marketing and consumer acceptance. J Funct Foods. 2008;51 (3):456–467.
Jantarska D, Ratkovska B, Kunachowicz H. Enrichment of food – the declared and actual. Przem Spoż. 2007;1:24–27 [in Polish].
Conte F, Scarantino S. A study on the quality of bovine colostrum: physical, chemical and safety assessment. Int Food Res J. 2013;20(2):925–931.
Rak KA, Bronkowska M. Immunological role of colostrum. Hygeia Public Health. 2014;49(2):249–254 [in Polish].
Langer P. Differences in the composition of colostrum and milk in eutherians reflect differences in immunoglobulin transfer. J Mammal. 2009;90(2):332–339.
Gapper LW, Copestake DE, Otter DE, Indyk HE. Analysis of bovine immunoglobulin G in milk, colostrum and dietary supplements. Anal Bioanal Chem. 2007;389(1):93–109.
Kehoe SI, Jayarao BM, Heinrichs AJ. A survey of bovine colostrum composition and colostrum management practices on Pennsylvania dairy farms. J Dairy Sci. 2007;90(9):4108–4116.
Shen RL, Thymann T, Østergaard MV, et al. Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs. Am J Physiol Gastrointest Liver Physiol. 2015;309(5):310–323.
Stelwagen K, Carpenter E, Haigh B, Hodgkinson A, Wheeler TT. Immune components of bovine colostrum and milk. J Anim Sci. 2009;87(13):3–9.
Elfstrand L, Lindmark-Månsson H, Paulssona M, Nybergc L, Akesson B. Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing. Int Dairy J. 2002;12(11):879–887.
Moore M, Tyler WJ, Chigerwe M, Dawes ME, Middleton JR. Effect of delayed colostrum collection on colostral IgG concentration in dairy cows. J Am Vet Med Assoc. 2005;226(8):1375–1377.
Dang AK, Kapila S, Singh MP. Changes in colostrum of Murrah buffaloes after calving. Trop Anim Health Prod. 2009;41(7):1213–1217.
Mills S, Ross RP, Hill C, Fitzgerald GF, Stanton C. Milk intelligence: mining milk for bioactive substances associated with human health. Int Dairy J. 2001;21(6):377–401.
Zwierzchowski G, Miciński J, Górecka-Ordon E, Goławski P. Is food allergy a civilization-related disease? Pol Ann Med. 2011;18(1):168–176.
Miciński J, Zwierzchowski G, Kowalski IM, Szarek J, Pierożyński B, Raistenskis J. The effect of bovine milk fat on human health. Pol Ann Med. 2012;19(2):170–175.
Houser BA, Donaldson SC, Kehoe SI, Heinrichs AJ, Jayarao BM. A survey of bacteriological quality and the occurrence of salmonella in raw bovine colostrum. Foodborne Pathog Dis. 2008;5(6):853–858.
Miciński J, Kowalski I, Zwierzchowski G, Szarek J, Pierożyński J, Zabłocka E. Characteristics of cow's milk proteins including allergenic properties and methods for its reduction. Pol Ann Med. 2013;20(1):69–76.
Minkiewicz P, Miciński J, Darewicz M, Bucholska J. Biological and chemical databases for research into the composition of animal source foods. Food Rev Int. 2013;29(4):321–335.
Li H, Aluko RE. Bovine colostrum as a bioactive product against human microbial infections and gastrointestinal disorders. Curr Top Nutraceut Res. 2006;4(3–4):227–237.
Beyer M, Jentsch W, Kuhla S, et al. Effects of dietary energy intake during gestation and lactation on milk yield and composition of first, second and fourth parity sows. Arch Anim Nutr. 2007;61(6):452–468.
Sponseller JK, Steele JA, Schmidt DJ, et al. Hyperimmune bovine colostrum as a novel therapy to combat Clostridium difficile infection. J Infect Dis. 2015;211(8):1334–1341.
Lawrence RM, Pane CA. Human breast milk: current concepts of immunology and infectious diseases. Curr Probl Pediatr Adolesc Health Care. 2007;37(1):7–37.
Benson KF, Carter SG, Patterson KM, Patel D, Jensen GS. A novel extract from bovine colostrum whey supports antibacterial and anti-viral innate immune functions in vitro and in vivo I. Enhanced immune activity in vitro translates to improved microbial clearance in animal infection models. Prev Med. 2011;54:116–123.
Bagwe S, Tharappel LJ, Kaur G, Buttar HS. Bovine colostrums: an emerging nutraceutical. J Complement Integr Med. 2015;12(3):175–185.
Menchetti L, Traina G, Tomaselo G, et al. Potential benefits of colostrums in gastrointestinal diseases. Front Biosci. 2016;8(1):331–351.
Legrand D, Elass E, Carpentier M, Mazurier J. Lactoferrin: a modulator of immune and inflammatory responses. Cell Nol Life Sci. 2005;62(22):2549–2559.
Wheeler TT, Hodgkinson AJ, Prosser CG, Davis SR. Immune components of colostrums and milk: a historical perspective. J Mammary Gland Biol Neoplasia. 2007;12(4):237–247.
Playford RJ. Peptide therapy and the gastroenterologist: colostrum and milk derived growth factors. Clin Nutr. 2001;20(1):101–116.
Bhora F, Dinkin B, Batzri S, et al. Effect of growth factors on cell proliferation and epithelization in human skin. J Surg Res. 1995;59:236–244.
Marnila P, Korhonen H. Milk and colostrum. Enc Diary Sci. 2011;84(1):591–597.
Bessler HC, De Oliveira IR, Giugliano LG. Human milk glycoproteins inhibit the adherence of Salmonella typhimurium to HeLa cells. Microbiol Immunol. 2006;50:877–882.
França EL, Bitencourt RV, Fujimori M, de Morais TC, Calderon Ide M, Honorio-Franca AC. Human colostral phagocytes eliminate enterotoxigenic Escherichia coli opsonized by colostrums supernant. J Microbiol Immunol. 2011;44:1–7.
Marnila P, Rokka S, Rehnberg-Laiho L, et al. Prevention and suppression of Helicobacter felis infection in mice using colostral preparation with specific antibodies. Helicobacter. 2003;8(3):192–201.
Tran CD, Kritas S, Campbell MA, Huynh HQ, Lee SS, Butler RN. Novel combination therapy for the eradication of Helicobacter pylori infection in a mouse model. Scand J Gastroenterol. 2010;45(12):1424–1430.
Singh PK, Parsek MR, Greenberg EP, Welsh MJ. A component of innate immunity prevents bacterial biofilm development. Nature. 2002;417:552–555.
Wong EB, Mallet JF, Duarte J, Matar C, Ritz BW. Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4. J Food Nutr Res. 2014;34(4):318–325.
Diarra MS, Petitclerc D, Lacasse P. Effect of lactoferrin in combination with penicillin on the morphology and the physiology of Staphylococcus aureus isolated from bovine mastitis. J Dairy Sci. 2002;85:1141–1149.
Pontoppidan PE, Shen RL, Cilieborg MS, et al. Bovine colostrum modulates myeloablative chemotherapy-induced gut toxicity in piglets. J Nutr. 2015;145(7):1472–1480.
Eliassen LT, Berge G, Sveinbjornsson B. Evidence for a direct antitumor mechanism of action of bovine lactoferricin. Anticancer Res. 2002;22:2703–2710.
Fischer W, Gustafsson L, Mossberg AK, et al. Human alphalactoalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosislike mechanism and prolongs survival. Cancer Res. 2004;64:2105–2112.
Bodammer P, Maletzki C, Waitz G, Emmrich J. Prophylactic application of bovine colostrum ameliorates murine colitis via induction of immunoregulatory cells. J Nutr. 2011;141(6):1056–1061.
Jensen ML, Sangild PT, Lykke M, et al. Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets. Am J Physiol Regul Integr Comp Physiol. 2013;305(1):4–12.
Biosci F. Potential benefits of colostrums in gastrointestinal diseases. Front Biosci. 2016;8(1):331–351.
Struff WH, Sprotte G. Bovine colostrum as a biologic in clinical medicine. Int J Clin Pharmacol Ther. 2008;46(5):211–225.
Tsabouri S, Douros K, Priftis KN. Cow's milk allergenicity. Endocr Metab Immune Disord Drug Targets. 2014;14(1):16–26.
Miciński J, Klupczyński J. Correlations between polymorphic variants of milk proteins and milk yield and chemical composition in black-and-white and jersey cows. Pol J Food Nutr Sci. 2006;15(56s):137–143.
Miciński J, Zwierzchowski G, Kowalski I, Szarek J. Healthpromoting properties of selected milk components. J Elem. 2013;18(1):165–186.