Propolis alcohol extract attenuates prostate specific antigen disorders and prostate necrosis induced by the cadmium toxicity in rats
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Laboratory of Water Resources and Environment, Biology Department, Faculty of Sciences, Dr. Tahar-Moulay University, Saida, Algeria
Abdelkrim Berroukche   

Research Laboratory of Water Resources and Environment, Biology Department, Faculty of Sciences, Dr Tahar-Moulay University, 20000 Saida, Algeria. Phone: +213555972162.
Submission date: 2017-02-14
Acceptance date: 2017-10-30
Online publication date: 2018-01-30
Publication date: 2019-11-17
Pol. Ann. Med. 2018;25(1):85–90
Cadmium, heavy metal, is causing toxicity. Propolis is a natural product derived from plant resins collected by honeybees. Studies reported this substance is an antioxidant and antitumor.

The aim of this study is to assess the effects of the propolis alcohol extract (PAE) against the prostate specific antigen (PSA) disorders and prostate necrosis induced by the cadmium (Cd) toxicity in rats.

Material and methods:
Parameters as body weight gain, blood PSA, blood Cd2+ and prostate tissue examination were performed in four groups of rats as follow: GR1 (controls), GR2 (administered orally with CdSO4 at the dose 28 mg / kg BW), GR3 (exposed to CdSO4 then treated orally with PAE at the dose 250 mg / kg BW) and GR4 (PAE/CdSO4 in the same conditions). Experimental period was 35 days.

Results and discussion:
Cadmium toxicity induced a decrease in body weight gain and an increase in prostate gland weight, blood PSA and Cd2+ levels. Cd also induced prostate necrosis in which it was noted a marked irregular acini and solid parenchyma. Whereas the treatment of animals with PAE revealed that body weight gain and blood PSA are low. Propolis increased preventive effects in rat’s prostate in GR4 better than GR3. Propolis has beneficial effects and could antagonize Cd-induced prostate toxicity.

The results showed that propolis antagonized the harmful effects of CdSO4. These findings showed that propolis could protect the human health through preventing the prostatic diseases.

The authors wish to thank Dr Z. Haddi for helping biochemical analysis and for his assistance in histological techniques.
There is no conflict of interest for all authors.
No funding was received for the work described in this article.
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