REVIEW PAPER
Interleukin 35: An overview
 
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1
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland
2
Department of Obstetrics, Perinatology and Gynecology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Poland
CORRESPONDING AUTHOR
Natalia Zdanowska   

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Wojska Polskiego 30, 10-229 Olsztyn, Poland. Tel.: +48 502 232 591.
Submission date: 2019-12-26
Final revision date: 2020-06-18
Acceptance date: 2020-07-10
Online publication date: 2020-10-31
 
Pol. Ann. Med. 2020;27(2):225–229
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Interleukin 35 (IL-35) has recently been characterized as a cytokine connected with the IL-12 group. The secretion of IL-35 was described in forkhead box protein 3 (Foxp3) + regulatory T cells (Tregs), peripheral γδ T cells, CD8+ T cells, placental trophoblasts, antigen-presenting cells (APCs) and regulatory B cells (Breg).

Aim:
The aim of this paper is to systematize current knowledge about IL-35 production and discuss its impact on the pathophysiology and outcome of various diseases.

Material and methods:
Literature review was conducted.

Results and discussion:
IL-35 plays a pivotal role in the immune dysregulation in the pathogenesis of cardiovascular diseases including atherosclerosis, psychiatric and neurologic disorders, cancer, allergic and autoimmune diseases and psoriasis, inducing the expression of Treg-related cytokines and inhibiting the expression of Th1- and Th17-related cytokines.

CONFLICT OF INTEREST
None declared.
FUNDING
None declared.
 
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