The potential benefits of plant cyclitols in the treatment of psoriasis
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Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Poland
Department of Plant Physiology, Genetics and Biotechnology, University of Warmia and Mazury in Olsztyn, Poland
Submission date: 2017-06-10
Acceptance date: 2017-08-16
Online publication date: 2018-02-23
Publication date: 2019-11-18
Corresponding author
Agnieszka Owczarczyk-Saczonek   

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Wojska Polskiego 30, 10-229 Olsztyn, Poland. Tel.: +4889 678 66 70, Fax: +4889 678 66 75.
Pol. Ann. Med. 2018;25(1):166-171
Cyclitols, the hydroxylated cycloalkanes biosynthetically derived from glucose, occur in all living cells and express a broad spectrum of biological activity and participate in many cellular processes including membrane biogenesis, signal transduction, ion channel physiology, osmoregulation, and antioxidation. They have several health-promoting and therapeutic properties such as: improving lipid profile in decresing of serum triglicerydes and total cholesterol, as well as having an insulin-mimetic effect. Moreover, they have antioxidative, anti-inflammatory and anti-cancer properties.

Revision the literature and analysis of available studies on the potential beneficial effects of cyclitols on inflammatory processes in psoriasis.

Results and discussion:
This article discusses the potential anti-inflammatory properties of cyclitols affecting the individual elements of the pathophysiology of psoriatic inflammation: inhibits the expression of MHC class I and MHC class II of mature dendritic cells, resulting in a decrease of IL-12, IL-23, which are necessary to differentiation of naive lymphocytes in Th1 and Th17 line; inhibits NF-κB, a major signaling pathway activated by TNF-α with reducing of inflammation; inhibits the angiogenic factor VEGF, with reducing epidermal hyperproliferation and enhance of the activity of antioxidants

The anti-inflammatory effects of cyclitols suggest that they can be used for treatment of psoriasis.

This work was financed within the framework of the grant entitled: ‘Cultivated plants and natural products as a source of biologically active substances destined for the production of cosmetic and pharmaceutical products as well as diet supplements’ (No. BIOSTRATEG2/298205/9/NCBR/2016) awarded by the National Center for Research and Development.
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